PREDICTORS OF ACUTE LIVER INJURY
IN COVID-19 PATIENTS IN SAIFUL ANWAR GENERAL HOSPITAL MALANG
Hana Nadya*, Supriono**
*Internal Medicine Resident
Brawijaya University Faculty of Medicine, Saiful Anwar General Hospital Malang
**Gastroenterohepatology Division Supervisor, Internal Medicine Departement, Medical Faculty. Brawijaya University, Saiful Anwar General Hospital Malang
BACKGROUND: Liver involvement in COVID-19 still remains a challenge until now. Meanwhile, some evidence have shown that COVID-19 patients with acute liver injury
(ALI) associated with bad prognosis. There is not much data available regarding the predictors of acute liver injury in COVID-19 patients.
OBJECTION: To evaluate the significant predictors of acute liver injury in COVID-19 patients.
METHODS: Our study is an observational analytic case control study, conducted from March 2020 to March 2021. The subject of the study are patients with confirmed diagnosis of COVID-19 who were hospitalized in Saiful Anwar General Hospital Malang. The inclusion criteria is those with the result of liver function test data. The exclusion criteria is history of malignancy, autoimmune, and drug use that can affect the liver function.
RESULT: We evaluated 54 COVID-19 patients who were divided into two groups, Acute Liver Injury (ALI) and non-ALI. We found that a high Body Mass Index (BMI) and liver cirrhosis are significant predictors of the incidence of acute liver injury in COVID-19 patients. The probability (p value) of high BMI and cirrhosis liver disease predictors are p= <0,0001 and p=0,0480 respectively.
CONCLUSION: Our study identifies the predictors of acute liver injury in COVID-19 patients, including high level of BMI and liver cirrhosis. Our findings can be used as an additional evaluation measure in the management of acute liver injury in COVID-19 patient.
KEYWORDS: acute liver injury, COVID-19, predictors