Association between Nutritional Status and Degree of Liver Fibrosis with Transient Elastography in Non Alcoholic Fatty Liver Disease Patients

Evelyn Joslin Salli*, Fardah Akil

 

*Faculty of Medicine, Hasanuddin University, Makassar-Indonesia

*Corresponding Author: evelynjsln1@gmail.com

ABSTRACT

 

Introduction: Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease worldwide and comes with a high disease burden. NAFLD has a global prevalence of 25% and is a leading cause of cirrhosis and hepatocellular carcinoma. (1)

Background: NAFLD is a silent disease with few or no symptoms. NAFLD closely related with obesity. We can measure nutritional status with  Body Mass Index (BMI). The gold standard for

NAFLD diagnosis still remains the liver biopsy. However, in recent years many noninvasive methods were invented, such as transient elastography (TE). TE is used for diagnosis of pathological differences of liver stiffness measurement. (2,3)

Objective: To find out the relationship between nutritional status and degree of liver fibrosis with transient elastography in non alcoholic fatty liver disease patients.

Method: This research is observational analytic with a cross sectional study design of NAFLD patients between April -June 2019 in Wahidin Sudirohudoso Hospital, Makassar-Indonesia.

Results: Total patients who have liver fibrosis are 30 patients with significance value (p) using Chi Square p=0.824. They are 13 (43.3%) male and 17 (56.7%) female with median age 51 y.o. Underweight patient with mild liver fibrosis 1 patient. Normal patient with mild liver fibrosis 5 patients and with moderate severe liver fibrosis 1 patient. Overweight patient with mild liver fibrosis 9 patients and with moderate severe liver fibrosis 1 patient. Obese 1 patient with mild liver fibrosis 10 patients and with moderate severe liver fibrosis 3 patients.

Conclusion: The result of this study indicate that there is no relationship between nutritional status and degree of liver fibrosis with transient elastography in non alcoholic fatty liver disease patients.

Keyword: Nutritional Status, Liver Fibrosis, Transient Elastography, Non Alcoholic Fatty Liver Disease